Isobutyl nitrite
Isobutyl nitrite
CAS: 542-56-3
Molecular Formula: C4H9NO2
Isobutyl nitrite - Names and Identifiers
| Name | Isobutyl nitrite |
| Synonyms | IBN Blackjack blackjack HSDB 4368 NCI-C61052 CCRIS 1099 BRN 1699518 Isobutylnitrite i-Butyl nitrite ISOBUTYL NITRITE Isobutyl nitrite 2-METHYLPROPYL NITRITE 2-methylpropyl nitrite Nitrous acid, isobutyl ester Nitrous acid, 2-methylpropyl ester 4-01-00-01595 (Beilstein Handbook Reference) Isobutyl nitrite, stabilized with potassium carbonate |
| CAS | 542-56-3 |
| EINECS | 208-819-7 |
| InChI | InChI=1/C4H9NO2/c1-4(2)3-7-5-6/h4H,3H2,1-2H3 |
| InChIKey | APNSGVMLAYLYCT-UHFFFAOYSA-N |
Isobutyl nitrite - Physico-chemical Properties
| Molecular Formula | C4H9NO2 |
| Molar Mass | 103.12 |
| Density | 0.87g/mLat 25°C(lit.) |
| Boling Point | 66-67°C(lit.) |
| Flash Point | −6°F |
| Vapor Presure | 140mmHg at 25°C |
| Appearance | clear liquid |
| Color | Light yellow to Yellow to Orange |
| Exposure Limit | ACGIH: Ceiling 1 ppm |
| Merck | 14,5149 |
| BRN | 1699518 |
| Storage Condition | 0-6°C |
| Stability | Stable. Incompatible with acids, alcohols, strong bases. Decomposes slowly in water. Flammable - incompatible with strong oxidizing agents. Note wide explosion limits. May be light and moisture sensit |
| Sensitive | Light Sensitive/Air Sensitive |
| Refractive Index | n20/D 1.373(lit.) |
| Physical and Chemical Properties | Isobutyl nitrite is an organic material, stored in a cool, dry, well-ventilated warehouse. Keep away from fire and heat source. Protected from light. Storage temperature should not exceed 37 ℃. Keep the container sealed. It should be stored separately from the oxidant, and mixed storage should not be avoided. Explosion-proof lighting and ventilation facilities shall be adopted. The use of spark-prone mechanical equipment and tools is prohibited. The storage area shall be provided with emergency handling equipment for leakage and appropriate containment materials. |
Isobutyl nitrite - Risk and Safety
| Risk Codes | R45 - May cause cancer R11 - Highly Flammable R20/22 - Harmful by inhalation and if swallowed. R68 - Possible risk of irreversible effects |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2351 3/PG 2 |
| WGK Germany | 3 |
| RTECS | RA0805000 |
| TSCA | Yes |
| HS Code | 29209090 |
| Hazard Note | Irritant/Highly Flammable/Keep Cold/Air Sensitive/Light Sensitive |
| Hazard Class | 3 |
| Packing Group | II |
Isobutyl nitrite - Reference Information
| (IARC) carcinogen classification | 2B (Vol. 122) 2019 |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Organic raw material | Isobutyl nitrite is an organic raw material that can be used as a solvent and organic synthesis. It is a nitrite compound. The main function of nitrite compounds is to dilate blood vessels, cause blood pressure drop and cardiac acceleration, but large doses can cause methemoglobinemia. Among them, isobutyl nitrite has aphrodisiac effect, similar to cocaine, heroin and other drugs. In the production process of cosmetics, due to raw material problems, it is possible to bring these two substances (isobutyl nitrite and amyl nitrite) into cosmetics, which are irritating to the eyes, skin, etc. after contact, and can further develop For skin allergies, and there is a risk of cancer; my country's cosmetics hygiene regulations stipulate that isobutyl nitrite is a banned component in cosmetics, the detection reports of these two nitrite compounds at home and abroad mainly focus on the exercise in biological samples, and the methods mainly involve gas chromatography. Figure 1 shows the determination of isobutyl nitrite and amyl nitrite in cosmetics by gas chromatography. |
| current situation of domestic and foreign industries | isobutyl nitrite belongs to nitrite compounds. the main function of nitrite compounds is to dilate blood vessels, cause blood pressure drop and cardiac acceleration, but high-dose use can cause methemoglobinemia. Among them, nitrite iso-butyl vinegar has a similar effect to cocaine, heroin and other drugs. In the production process of cosmetics, due to the problem of raw materials, it is possible to bring these two substances into cosmetics. After contact, they are irritating to the eyes and skin, can develop, cause skin allergies, and have the risk of cancer, etc.; my country Cosmetics Hygiene Regulations stipulate, isobutyl nitrite vinegar is a banned component in cosmetics. "The detection reports of these two nitrite compounds at home and abroad mainly focus on the positive habit in biological samples, and the method mainly involves gas chromatography. |
| safety information | hazardous characteristics: flammable, easy to cause combustion in case of open flame and high heat, and release toxic gases. The toxic nitrogen oxide flue gas is released by thermal decomposition. Combustion (decomposition) products: carbon monoxide, carbon dioxide, nitrogen oxides. protective measures respiratory system protection: when you may contact its vapor, wear a self-priming filter gas mask (full mask). Wear an oxygen respirator for emergency rescue or evacuation. Eye protection: Wear chemical safety protective glasses. Body protection: wear anti-toxin penetration work clothes. Hand protection: Wear latex gloves. Others: Smoking, eating and drinking are prohibited at the work site. Pay special attention to the protection of eyes and respiratory tract. After the work, clean it thoroughly. Store clothes contaminated with poison separately and wash them for later use. first aid measures skin contact: remove contaminated clothes and rinse skin thoroughly with soapy water and clear water. Eye contact: Lift the eyelids and rinse with flowing water or normal saline. Medical treatment. Inhalation: Quickly leave the scene to fresh air. Keep the airway unobstructed. If breathing is difficult, give oxygen. If breathing stops, artificial respiration is performed immediately. Medical treatment. Intake: Drink enough warm water, induce vomiting, and seek medical treatment. fire extinguishing method: fire extinguishing agent: foam, carbon dioxide, dry powder, sand. Firefighters must wear filter gas masks (full masks) or isolated respirators, and wear full-body fire and anti-virus clothing to extinguish the fire in the upper wind. Spray water to keep the fire container cool until the fire is extinguished. |
| references | 1. leap junxiu, Li qiong, Cui jianjie, Wu xiaojian, determination of isobutyl nitrite and amyl nitrite in cosmetics by gas chromatography, physical and chemical detection-chemical analysis [J],2013(49),222-227. |
| category | flammable liquid |
| toxicity classification | highly toxic |
| acute toxicity | oral-rat LD50: 410 mg/kg; Oral-mouse LD50: 205 mg/kg |
| flammability hazard characteristics | flammable in case of open flame, high temperature and oxidant;; Combustion produces toxic nitrogen oxide smoke; Toxic nitrogen oxide gas in case of light |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; Store separately from oxidants and acids |
| fire extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
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